Recent Publications (2023-2024)
Summury report: Involving and Engaging People with Cancer in Oncology Drug Development
White paper: Histology independent drug development – Is this the future for cancer drugs?
Cancer Treatment Reviews, 22 Dec 2023
Pragmatic solutions for optimizing oncology drug development trials
Comprehensive Precision Medicine, Elsevier, Volume 2, 2024, page 293-303
Interview article: Collaboration and Partnerships in Accelerating Cancer Drug Development
Open Access Government, April 2024, page118-121
Past Publications
European Groundshot—addressing Europe’s cancer research challenges: a Lancet Oncology Commission
The Lancet Oncology, November 2022
Cancer World publication: Mark Lawler comments on the conclusions of a UK consensus group (September 2022)
United efforts to accelerate drug development
European Pharmaceutical Review, December 2021
Access to Personalised Oncology in Europe : a report by LSE consulting, commissioned by EFPIA and contributed by the CDDF (November 2020)
ESMO provides first recommendations on use of next-generation sequencing in metastatic cancer
Cancerworld, September 2020
Verweij, J., Hendriks, H.R., Zwierzina, H. (2019) – on behalf of the CDDF. Innovation in oncology clinical trial design. Cancer Treatment Reviews, 74, 15-20.
https://doi.org/10.1016/j.ctrv.2019.01.001
Biomarkers and patients’ access to personalised oncology drugs in Europe
Open Access Government, January 2019
The use of real-world data in cancer drug development
European Journal of Cancer (EJC), Volume 101, pp. 69-76, September 2018
Access the article in PDF format.
The Current and Future Challenges of Personalised Cancer Therapy
Open Access Government, April 2018
5th Immunotherapy of Cancer Conference (ITOC5), 19-21 March 2018, Berlin, Germany – Abstract Book
European Journal of Cancer (EJC), Volume 92, Supplement 1, S1-S26, March 2018
Implementing liquid biopsies into clinical decision making for cancer immunotherapy
Oncotarget, doi: 10.18632/oncotarget.17397, April 2017
4th Immunotherapy of Cancer Conference (ITOC4), 20-22 March 2017, Prague, Czech Republic – Abstract Book
Journal for Immunotherapy of Cancer 2017 5 (Suppl 1):12, 20 March 2017
Accelerating progress in immunotherapy
Cancerworld, n°71 – Cutting Edge section, pp. 29, March, April, 2016
Regulators Embrace Immunotherapy
J. Smyth – The ASCO Post, 25 March 2016
3rd Immunotherapy of Cancer Conference (ITOC3), 21-23 March 2016, Munich, Germany – Abstract Book
European Journal of Cancer (EJC), Volume 55, Supplement 1, March 2016
Access to innovative oncology medicines in Europe
L. Bergmann, H. Enzmann, S. Thirstrup, J. K. Schweim, I. Widera, and H. Zwierzina
Ann. Onc. 2016 27: 353-356, November 2015
2nd Immunotherapy of Cancer Conference (ITOC2), 25-27 March 2015, Munich, Germany – Abstract Book
European Journal of Cancer (EJC), Volume 51, Issue S1, pp. S1-S14, March 2015
Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer
European Journal of Cancer (EJC), Volume 51, Issue 2, pp. 218-224, January 2015
Actual developments in European regulatory and health technology assessment of new cancer drugs – what does this mean for oncology in Europe?
L. Bergmann, H. Enzmann, K. Broich, A. Hebborn, S. Marsoni, L. Goh, J. F. Smyth and H. Zwierzina. Ann Oncol (2014) 25 (2): pp. 303-306. doi: 10.1093/annonc/mdt488 First published online: 10 December 2013
Present and future breast cancer management—bench to bedside and back
A positioning paper of academia, regulatory authorities and pharmaceutical industry
R. Bartsch1,2, S. Frings3, M. Marty4, A. Awada5, A. S. Berghoff1,2, P. Conte6, S. Dickin7,
H. Enzmann8, M. Gnant2,9, M. Hasmann10, H. R. Hendriks11, A. Llombart12, C. Massacesi13,
G. von Minckwitz14,15, F. Penault-Llorca16,17, M. Scaltriti18, Y. Yarden19, H. Zwierzina20 &
C. C. Zielinski1,2* for the Biotherapy Development Association (BDA)
BDA 7th Alpine meeting: Meeting the Current and Future Challenges of Oncology Drug Development
Breakout session on “The Current and Future Challenges of Targeted Therapy in HTA Evaluation” Moira Howie, Kathy Oliver, Angela Timoney and Gordon McVie.
Ecancer, published 23 may 2013
The preclinical and clinical activity of aviscumine: a potential anticancer drug.
Zwierzina H, Bergmann L, Fiebig H, Aamdal S, Schöffski P, Witthohn K, Lentzen H.
Eur J Cancer. 2011;47(10):1450-7.
Molecularly targeted therapies for colorectal cancer: Strategies for implementing translational research in clinical trials.
Zwierzina H, Bardelli A, Ciardiello F, Gariboldi M, Håkansson L, Lambrechts D, Lind GE, Loeffler-Ragg J, Schmoll H, Siena S, Tabernero J, Van Cutsem E.
Curr Opin Mol Ther 2010;12(6):703-11
Investigator-initiated trials of targeted oncology agents: why independent research is at risk?
Bergmann L, Berns B, Dalgleish AG, von Euler M, Hecht TT, Lappin GL, Reed N, Palmeri S, Smyth J, Embacher-Aichorn S, Zwierzina H; Biotherapy Development Association.
Ann Oncol 2010;21(8):1573-8.
The capacity of the immune system to control cancer
Håkansson L.
Eur J Cancer 2009;45(12):2068-70.
Improving the efficacy of cancer immunotherapy
Copier J, Dalgleish AG, Britten CM, Finke LH, Gaudernack G, Gnjatic S, Kallen K, Kiessling R, Schuessler-Lenz M, Singh H, Talmadge J, Zwierzina H, Håkansson L.
Eur J Cancer 2009;45(8):1424-31.
Market and patient access to new oncology products in Europe: a current, multidisciplinary perspective
McCabe C, Bergmann L, Bosanquet N, Ellis M, Enzmann H, von Euler M, Jönsson B, Kallen KJ, Newling D, Nüssler V, Paschen B, de Wilde R, Wilking N, Teale C, Zwierzina H; Biotherapy Development Association.
Ann Oncol 2009;20(3):403-12. Review.
Phase I trial of r viscumin (INN: aviscumine) given subcutaneously in patients with advanced cancer: a study of the European Organisation for Research and Treatment of Cancer (EORTC protocol number 13001)
Bergmann L, Aamdal S, Marreaud S, Lacombe D, Herold M, Yamaguchi T, Wilhelm-Ogunbiyi K, Lentzen H, Zwierzina H; European Organisation for Research and Treatment of Cancer.
Eur J Cancer 2008;44(12):1657-62.
Strategies for harmonization of next-generation oncology drug development. A report from the third Alpine meeting of the Biotherapy Development Association.
Guest Editors: Zwierzina H, Bergmann L, deBock A, Hirschfeld S.
Eur J Cancer Supplements 2007;5(9): pp. 1-52.
Pharmacoeconomics behind next-generation oncology drug development.
H. Zwierzina a, J. Liliemark b, A. deBock, pp. 2.
The basic economic problem – interaction of all stakeholders required. p4-5
Max E. Scheulen, pp.4-5.
Erlotinib in pancreatic cancer.
L. Bergmann, J.W. Goethe, pp. 7-8.
Biomarkers and translational research.
V. Nuessler, P. Démolis, S. Schwoch, pp. 10.
Development of biomarkers: What are the scientific hurdles?
L. Håkansson, pp. 10-11.
Progression-free survival as an end-point in clinical trials of biotherapeutic agents.
Lothar Bergmann, Steven Hirschfeld, Charles Morris, Sergio Palmeri, pp. 23-28
Vaccines: A rapidly evolving technology – Are the hurdles being addressed?
L. Håkansson, A. Dalgleish, K.J. Kallen, M. Schuessler-Lenz, pp. 29-32.
How can biomarkers become surrogate endpoints?
B. Berns, P. Démolis, M.E. Scheulen. pp. 37-40.
Clinical trial design issues: Session 1.
R. Milsted, T. Hinz, C.C. Zielinski, pp. 41.
Clinical trial design issues: Session 2.
H.X. Chen, A. Tinetti, H. Zwierzina, pp. 46.
Phase I investigation of recombinant anti-human vascular endothelial growth factor antibody in patients with advanced cancer.
Jayson GC, Mulatero C, Ranson M, Zweit J, Jackson A, Broughton L, Wagstaff J, Hakansson L, Groenewegen G, Lawrance J, Tang M, Wauk L, Levitt D, Marreaud S, Lehmann FF, Herold M, Zwierzina H; European Organisation for Research and Treatment of Cancer (EORTC).
Eur J Cancer 2005;41(4):555-63.
Phase I trial of intravenous aviscumine (rViscumin) in patients with solid tumors: a study of the European Organization for Research and Treatment of Cancer New Drug Development Group.
Schöffski P, Riggert S, Fumoleau P, Campone M, Bolte O, Marreaud S, Lacombe D, Baron B, Herold M, Zwierzina H, Wilhelm-Ogunbiyi K, Lentzen H, Twelves C; European Organization for Research and Treatment of Cancer New Drug Development Group.
Ann Oncol 2004;15(12):1816-24.
Molecular imaging and biological evaluation of HuMV833 anti-VEGF antibody: implications for trial design of antiangiogenic antibodies.
Jayson GC, Zweit J, Jackson A, Mulatero C, Julyan P, Ranson M, Broughton L, Wagstaff J, Hakannson L, Groenewegen G, Bailey J, Smith N, Hastings D, Lawrance J, Haroon H, Ward T, McGown AT, Tang M, Levitt D, Marreaud S, Lehmann FF, Herold M, Zwierzina H; European Organisation for Research and Treatment of Cancer Biological Therapeutic Development Group.
J Natl Cancer Inst 2002;94(19):1484-93.
PET and PK analysis of the humanized monoclonal anti-VEGF antibody HuMV833. An EORTC Biological Treatment Group phase I study.
Gordon C. Jayson, Jamal Zweit, Clive Mulatero, David Hastings, Peter Julyan, Malcolm Ranson, Jeremy Lawrance, Alan McGown, Alan Jackson, Leif Hakannson, John Wagstaff, Gerard Groenwegen, Frederick Lehmann, John Wagstaff, Dan Levitt, Tao Tang, Heinz Zwierzina.
Proc AACR 2001,42, abstract 4470